Research

Clinical practice guidelines for the therapeutic use of repetitive transcranial magnetic stimulation in neuropsychiatric disorders

Author: Siddiqui, Ma. (2023)

  • Outlines clinical practice guidelines (CPG) as of 2023 by the Indian Psychiatric Society (IPS).
  • Notes positive evidence for TMS use in treating depression, GAD, OCD, PTSD, nicotine use disorder, migraine, and insomnia.
Regulatory Clearance and Approval of Therapeutic Protocols of Transcranial Magnetic Stimulation for Psychiatric Disorders

Author: Cotovio, G. (2023)

  • This article provides the latest clearance status of different TMS coils and protocols for various disorders as of 2023.
Transcranial Magnetic Stimulation in the Treatment of Neurological Diseases

Author: Somaa, F. (2022)

  • Outlines current data on the use of TMS in neurological diseases such as Parkinson’s Disease, Alzheimer’s Disease, Multiple Sclerosis, and Epilepsy.
Assessment of Non-invasive Brain Stimulation Interventions for Negative Symptoms of Schizophrenia

Author: Tseng, P. (2022)

  • Indicates possible improvement in negative symptoms of schizophrenia using non-invasive brain stimulation such as rTMS or tDCS.
  • The authors caution that the evidence is limited by small sample sizes and non-standard protocols.
Safety and Recommendations for TMS Use in Healthy Subjects and Patient Populations, with Updates on Training, Ethical and Regulatory Issues: Expert Guidelines

Author: Rossi, S. (2021)

  • Provides expert guidelines on safety recommendations for TMS use in research and clinical settings.
  • Summarizes basic requirements for research and clinical use of TMS.
Stanford Accelerated Intelligent Neuromodulation Therapy for Treatment-Resistant Depression

Author: Cole, E. (2020)

  • Describes the FDA-cleared SAINT Protocol for Accelerated TMS.
Evidence-Based Guidelines on the Therapeutic Use of Repetitive Transcranial Magnetic Stimulation (rTMS): An Update

Author: Lefaucheur, J.P. (2020)

  • Provides updated evidence-based recommendations.
  • Level A (definite efficacy):
    • High-frequency rTMS of the primary motor cortex (M1) contralateral to the painful side in neuropathic pain.
    • High-frequency rTMS of the left dorsolateral prefrontal cortex (DLPFC) in MDD using a figure-of-8 coil, but also a H1-coil.
    • Low-frequency rTMS of contralesional M1 in hand motor recovery at the postacute stage of stroke.
  • Level B (probable efficacy):
    • Fibromyalgia, Parkinson’s disease, post-traumatic stress disorder, chronic post-stroke non-fluent aphasia, and depression.
Efficacy and Safety of Deep Transcranial Magnetic Stimulation for Obsessive Compulsive Disorder: A Prospective Multicenter Randomized Double-Blind Placebo-Controlled Trial

Author: Carmi, L. (2019)

  • Discusses the trial that led to FDA clearance of Brainsway Deep TMS for OCD.
  • A 3–5 minute individualized symptom provocation was performed before each treatment to activate the relevant neuronal circuit.
Transcranial Magnetic Stimulation for Positive Symptoms in Schizophrenia: A Systematic Review

Author: Marzouk, T. (2019)

  • Systematic review with early promise about the use of TMS in auditory hallucinations, while noting limitations of small sample sizes and a lack of long-term follow-up data.
Effectiveness of Theta Burst versus High-Frequency Repetitive Transcranial Magnetic Stimulation in Patients with Depression (THREE-D): A Randomized Non-Inferiority Trial

Author: Blumberger, D.M. (2018)

  • Trial showing that intermittent Theta Burst Stimulation (iTBS) is non-inferior to High-Frequency rTMS in the treatment of depression.
Smoking Cessation Induced by Deep Repetitive Transcranial Magnetic Stimulation of the Prefrontal and Insular Cortices: A Prospective, Randomized Controlled Trial

Author: Dinur-Klein, L. (2014)

  • RCT demonstrating an almost 44% abstinence rate in smoking following deep TMS treatment.
Improvement in Quality of Life with Left Prefrontal Transcranial Magnetic Stimulation in Patients with Pharmaco-resistant Major Depression: Acute and Six Month Outcomes

Author: Solvason, H.B. (2014)

  • Demonstrates the improvement in Quality of Life (QoL) of MDD patients following a course of rTMS over the Left DLPFC.
Electric Field Depth–Focality Tradeoff in Transcranial Magnetic Stimulation: Simulation Comparison of 50 Coil Designs

Author: Deng, Z. (2013)

  • This article discusses coil design considerations for deep-brain transcranial magnetic stimulation (dTMS).
Efficacy and Safety of Transcranial Magnetic Stimulation in the Acute Treatment of Major Depression: A Multisite Randomized Controlled Trial

Author: O’Reardon, J.P. (2007)

  • Details the trial that was the basis for FDA clearance of rTMS for the treatment of depression.